British Journal of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied Pharmacology , Arnott DG, Doniach I The impact of compounds allied to resorcinol upon the uptake of radioactive iodine I by the thyroid of the rat. IARC evaluated the carcinogenicity of resorcinol in and concluded that there are not any epidemiological data relevant to the carcinogenicity of resorcinol in humans and that the evidence of its carcinogenicity in animals is insufficient; thus, resorcinol isn't classifiable as to its carcinogenicity to people. JECFA assessed the hazards from the use of resorcinol as a food flavouring agent and concluded that this use is of no safety concern. Overall, the studies are not enough for a statistical extrapolation technique based on the EU Technical Guidance Document EC, a.
Fifty per cent of survivors had been sacrificed 1 week later, and blood and urine samples were taken. Resorcinol confirmed a focus-dependent increase in labelling index [ three H]thymidine , acanthosis, and papillomatosis. After application of an ointment containing To research the goitrogenic activity of resorcinol, feminine Wistar rats had been treated twice day by day for 28 days by rubbing 6 g of an ointment containing Increased thyroid gland weights 2.
The organisms had been uncovered to the test concentrations for ninety six h. Biological observations had been performed every day.
For the benthic and terrestrial compartments, the out there toxicity information cannot be regarded as adequate for a quantitative risk characterization. However, these compartments are less related for resorcinol, due to marginal releases and emissions to these compartments in addition to a really low potential for adsorption of resorcinol to organic matter.
Animals that died showed hyperaemia and distension of stomach and intestine, while there were no gross lesions at necropsy in survivors Flickinger, In one other research with CFY rats. Most of the studies are of enough quality and acceptable for danger characterization purposes.
As is well-known in dermal absorption studies, the nature of the car has an excellent affect on the absorption of a compound. Resorcinol appears to be absorbed much better from anti-acne preparations than from the hair dye preparations underneath regular utilization circumstances.
Complete recovery in all animals occurred inside 1—1. Of the next research, the repeated-dose toxicity research that had been deemed to be most related to the danger assessment are summarized in Appendix 6. In a study carried out by NTP , 5 male and female F rats have been dosed with resorcinol in deionized water via gavage at zero, High-dose females had significantly decreased absolute and relative thymus weights. No different biologically vital differences in organ weights have been noticed. In distinction to those findings, Eastin et al.
- As is well-known in dermal absorption studies, the nature of the vehicle has an excellent influence on the absorption of a compound.
- In another examine, rats have been exposed to 0 or 0.
- Mean data for three donors and sixteen replicates point out a plateau in receptor fluid concentration between 24 and 48 h, as mirrored by cumulative absorption values of 1.
- In one research carried out with male Syrian golden hamsters, which focused solely on effects on the forestomach, pyloric region, and urinary bladder, the animals were dosed with zero or zero.
- Van Leeuwen et al.
From its use in topical medication and from restricted information from occupational research, resorcinol does not seem like irritating to the skin in the concentrations reported. Van Leeuwen et al. There isn't any indication as as to whether the teratogenic results had been endocrine mediated or not EC, c. In humans, dermal publicity to resorcinol has been reported to be associated with thyroid effects, CNS disturbances, purple blood cell changes, and a low incidence of pores and skin sensitization. Five of three.
In rodents, the upper sensitivity can be associated to a shorter plasma half-lifetime of T four than in people due to appreciable variations between species within the transport proteins for thyroid hormones. In plasma, the T 4 half-life is about 12—24 h in rats vs 5—9 days in humans, and the serum levels of TSH are about 25 times larger in rodents than in people.
The third research, performed in , included of lively employees. In subjects men, 13 girls with a imply age of 37 years, both laboratory and other checks, together with medical examination, were accomplished; no irregular thyroid glands or changes in T 4 values had been present in any of the subjects when compared with regular values Bauer, The above data are restricted due to small research sizes, lack of comparison teams, missing present and historic management information, and missing information regarding potential exposure classes. In a examine in a plant producing resorcinol by sulfonation of benzene — and also producing beta -resorcylic acid, resorcinol—formaldehyde resins, sulfites, and sulfates — staff have been exposed primarily to resorcinol, however the exposure to different agents was not measured for exposure ranges, see part 6. In this plant, three cross-sectional studies had been carried out between and Flickinger, In , medical examinations, chest X-rays, pulmonary operate, haematology, and clinical chemistry had been performed with of persons actively employed at a production plant in Pennsylvania, USA. In addition, male rats have greater circulating levels of TSH than females.
In in vitro genotoxicity exams, resorcinol confirmed largely adverse results. Results from all reported in vivo exams for genotoxicity were unfavorable. Mostly negative outcomes were reported within the initiation—promotion studies performed using a number of species. UV irradiation brought on no elevated pores and skin reactions. The iodination course of is catalysed by a haem-containing enzyme.
The elimination was biphasic, with half-lives of 18—21 min and 8. The 14 C activity was quickly distributed in major tissues such as muscles, kidneys, and liver, with out indication of bioaccumulation Merker et al. Any new information being provided in the middle of the OECD assessment might be supplied to the IPCS so that an addendum can be prepared for consideration.
From the scarce information obtainable, using resorcinol in hair dyes 0. The use of anti-acne cream is taken because the situation of most concern because of the chance of continuous publicity.
Thyroid glands from all surviving F zero parents were examined microscopically, and mind measurements were performed on all exposed F 1 pups and those F 1 pups selected for behavioural testing. There have been no vital intercourse differences. In females, a larger proportion was excreted as sulfate conjugate, whereas males excreted a higher proportion of a diconjugate both sulfate and glucuronide groups. From these data, the authors concluded that male rats have the next capability for glucuronidation than females.
Furthermore, persistent research with fish and Daphnia have been conducted. For the toxicity to aquatic plants, no guideline study is available. However, taking into account the out there research for toxicity to aquatic crops, the NOEC for algae could be assumed to be greater than that for Daphnia magna. Exposure to resorcinol by way of peeling agents presents an acute publicity state of affairs the place the person is exposed to a excessive focus 7. Acute results have been described under these conditions.