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These figures agree nicely with the above exposure estimate primarily based on the Yeung et al.

As is well known in dermal absorption research, the character of the vehicle has an excellent influence on the absorption of a compound. Resorcinol appears to be absorbed a lot better from anti-pimples preparations than from the hair dye preparations underneath normal usage circumstances.

British Journal of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied Pharmacology , Arnott DG, Doniach I The impact of compounds allied to resorcinol upon the uptake of radioactive iodine I by the thyroid of the rat. IARC evaluated the carcinogenicity of resorcinol in and concluded that there aren't any epidemiological data relevant to the carcinogenicity of resorcinol in humans and that the evidence of its carcinogenicity in animals is insufficient; thus, resorcinol just isn't classifiable as to its carcinogenicity to humans. ricorso per ingiunzione di pagamento assessed the hazards from using resorcinol as a food flavouring agent and concluded that this use is of no safety concern. ingiunzione di pagamento , the research are not sufficient for a statistical extrapolation approach based on the EU Technical Guidance Document EC, a.

• No thyroid hormone measurements were performed.





• Animals that died confirmed hyperaemia and distension of abdomen and intestine, whereas there have been no gross lesions at necropsy in survivors Flickinger, In another study with CFY rats.





• There are ingiunzione di pagamento in thyroid physiology between people and animals.





• In a examine carried out by Hasegawa et al.





• Furthermore, Cronin et al.





• Effects on the thyroid gland have been reported both in animal research and in case-stories in humans.





• Assuming a body weight of 64 kg IPCS, provides an exposure estimate of 0.

There were no printed animal research displaying thyroidal effects with a dose—response relationship that might be used for a tolerable intake. In the body of a full life cycle toxicity take a look at OECD TG , Lima observed no antagonistic results after forty eight h of exposure at the highest focus tested, 0. Furthermore, Cronin et al. The fish and pond snails were placed instantly into the aquaria, whereas the remaining five species were segregated in several baskets and suspended in the aquaria. The solely investigation into this finish-point is that from the dose range-discovering examine reported in sections eight.

For the benthic and terrestrial compartments, the available toxicity data cannot be thought to be sufficient for a quantitative threat characterization. However, these compartments are much less related for resorcinol, due to marginal releases and emissions to those compartments in addition to a really low potential for adsorption of resorcinol to natural matter.
Two lengthy-time period research with Swiss mice or NZW rabbits, the place the animals have been treated with zero. In an in vitro. In an investigation in three human volunteers using circumstances much like those used in hair dyeing, 14 C-ring-labelled 1. This suggests that only a small quantity of resorcinol penetrates the skin through the actual means of hair colouring.
Koppers Company studied attainable skin irritating results of flaked or industrial resorcinol in male albino rabbits mg underneath occlusive situations over 24 h, scoring after 24 and 72 h. In one examine performed with male Syrian golden hamsters, which centered solely on results on the forestomach, pyloric region, and urinary bladder, the animals had been dosed with zero or 0.