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In common, the h LC 50 values for resorcinol had been within the vary between In circulate-by way of exams and analytical monitoring, DeGraeve et al. As mentioned in section 9. Complete healing was famous after about 1 week of absence from work. However, with increasing resorcinol concentrations, there was additionally a rise within the variety of individuals who examined optimistic. Resorcinol was additionally examined in hairdressers, who may have been in contact with resorcinol-containing hair dyes.


Koppers Company studied attainable skin irritating results of flaked or industrial resorcinol in male albino rabbits mg underneath occlusive situations over 24 h, scoring after 24 and seventy two h. In one examine performed with male Syrian golden hamsters, which targeted solely on effects on the forestomach, pyloric region, and urinary bladder, the animals were dosed with zero or 0.


Determination of resorcinol conjugates in the h urine samples after 14 days of steady product treatment confirmed that a maximal 23 mg 2. Assuming a body weight of 64 kg IPCS, offers an exposure estimate of zero. In a report based mostly on shopper analysis knowledge Gans, , underneath cheap most-use situations i.
In both species, there were no antagonistic effects on final mean physique weights, haematology, or medical chemistry parameters, and no chemical-associated gross or microscopic lesions have been observed. In one other study, rats had been uncovered to 0 or 0. No thyroid hormone measurements have been performed.
The elimination was biphasic, with half-lives of 18—21 min and eight. The 14 C activity was rapidly distributed in main tissues corresponding to muscles, kidneys, and liver, without indication of bioaccumulation Merker et al. Any new info being provided in the middle of the OECD evaluation shall be supplied to the IPCS in order that an addendum could be ready for consideration.

The third examine, carried out in , included of lively staff. In topics males, thirteen ladies with a mean age of 37 years, both laboratory and different exams, together with medical examination, have been carried out; no irregular thyroid glands or modifications in T 4 values had been found in any of the subjects in comparison with normal values Bauer, The above knowledge are restricted as a result of small examine sizes, lack of comparability groups, missing current and historic management knowledge, and missing info concerning potential publicity categories. In a study in a plant producing resorcinol by sulfonation of benzene — and likewise producing beta -resorcylic acid, resorcinol—formaldehyde resins, sulfites, and sulfates — workers have been uncovered primarily to resorcinol, but the publicity to other agents was not measured for publicity ranges, see section 6. In this plant, three cross-sectional studies have been carried out between and Flickinger, In , medical examinations, chest X-rays, pulmonary perform, haematology, and medical chemistry have been carried out with of persons actively employed at a production plant in Pennsylvania, USA. In addition, male rats have larger circulating levels of TSH than females.

Resorcinol is understood to type covalent bonds with haem Sessler et al. Effects on the thyroid gland have been reported each in animal research and in case-stories in people. However, there are species variations in the susceptibility to goitrogens.